• International Stem Cell Guidelines Revised, Expanded

    In Allgemein on

    Widely recognized stem cell research guidelines now address controversial topics such as human gene editing.

    The decision by the International Society for Stem Cell Research to recommend that stem cell oversight bodies should review all embryo research comes from a recognition of rapidly advancing technologies that could make unprecedented advances in understanding human disease but also have ethical implications.

    “We in the scientific community have to be vigilant—and also transparent—about the way we do the research,” George Q. Daley, a Harvard University stem cell scientist and ISSCR board member who helped craft the new guidelines. The document is titled Guidelines for Stem Cell Science and Clinical Translation.

    To find out more, please clikc here.
    Download: ISSCR  guidelines.

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  • PELOBIOTECH: Meet us at… Analytica in Munich

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    Analytica is the International Trade Fair for Laboratory Technology, Analysis and Biotechnology. It´s meeting the 25th time this year from May 10-13, 2016, opening at 9 AM, in Munich. So meet us at our partner´s booth baseclick in Hall A3, booth A3, booth #313.

    Its unique exhibition profile unites all topics that pertain to modern analysis in research and industry. The various exhibition sectors will give you a comprehensive overview of the market.

    Download here the floorplan.

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  • S-stamp Marking Technique helps prevent Inverted Graft Implantation in DMEK

    In Allgemein, Cell Culture on

    Endothelial cell loss, re-bubbling and complication rates were similar in stamped and unstamped graft groups.

    A novel S-stamp marking method eliminated upside-down graft implantation in Descemet’s membrane endothelial keratoplasty, according to a study.

    The technique may help surgeons perfect the DMEK technique and avoid complications, according to Peter B. Veldman, MD, the corresponding author. To read more go to healio.

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  • FREE WEBINAR: Brandnew Media for Keratinocytes

    In Allgemein, Cell Culture, Webinar on

    Why, How and when is the Best Time to Switch to this Serum-free and Defined Media.

    presented by Lothar Steeb, PhD, CSO, PELOBIOTECH

    1. Tue, May 3, 2016 3:00 PM – 4:00 PM CEST (English)

      DEVELOPED BY PELOBIOTECH - FOR YOU!

      DEVELOPED BY PELOBIOTECH – FOR YOU!

    Please sign up and share this Information with your co-workers and friends. Thank you.

    Your PELOBiotech-Team

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  • Gene Editing Technique Improves Vision in Rats with Inherited Blindness

    In Allgemein, regenerative medicine on

    A Cedars-Sinai study has revealed that a research team at the Cedars-Sinai Board of Governors Regenerative Medicine Institute has discovered a new technique that has the potential to treat inherited diseases by removing genetic defects has been shown for the first time to hinder retinal degeneration in rats with a type of inherited blindness.

    The focus of the researchers was on inherited retinitis pigmentosa – a degenerative eye disease with no known cure that can lead to blindness. Â A technique called CRISPR/Cas9 was used by the researchers to remove a genetic mutation that causes the blindness disease.

    The technique CRISPR/Cas9 (CRISPR stands for Clustered Regularly Interspaced Short Palindromic Repeat, the type of DNA sequences involved in this process) is adapted from a strategy used by bacteria to fight invading viruses. The study was carried out in mice, however the finding are significant as they have potential implication sin humans as well. The details of the study findings were published recently in the journal Molecular Therapy.
    To read more, please click here.

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  • Researchers Create Micro Heart Muscle From Stem Cells

    In Allgemein on

    The medical research field has been looking into creating better solutions for delicate yet complex procedures that require utmost precision when dealing with heart problems and stem cell therapy is one of the possible solutions for treating heart failure.

    Luckily, Gladstone Institutes, whose mission is to overcome major unsolved diseases, has just given coronary disease researchers an excellent tool to advance methods and medicines for heart problems with its latest breakthrough.

    To read more please click here.

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  • FREE WEBINAR: Let your Primary Cells be in the SPA-Oasis

    PELOBIOTECH. Join your FREE WEBINAR. How to Develop and Optimize your Media/Wie im Paradies: Medienentwicklung und –optimierung für Primäre Zellen

     

    1. Tue, 26. April 2016, 15:00 – 16:00 MESZ

    presented by Lothar Steeb, PhD, CSO, PELOBIOTECH

    Please share this Information with your co-workers and friends. Thank you.

    Your PELOBiotech-Team

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  • Flawed Mitochondrial DNA Could Undermine Stem Cell Therapies

    Mutations in our mitochondrial DNA tend to be inconspicuous, but they can become more prevalent as we age. They can even vary in frequency from cell to cell. Naturally, some cells will be relatively compromised because they happen to have a higher percentage of mutated mitochondrial DNA. Such cells make a poor basis for stem cell lines. They should be excluded. But how?

    To read Details, click here

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  • Damaging Consequences of Zika Virus Infection in Human Minibrains

    In Allgemein on

    Brazilian researchers from the D’Or Institute for Research and Education (IDOR) and Federal University of Rio de Janeiro (UFRJ) have demonstrated the harmful effects of ZIKA virus (ZIKV) in human neural stem cells, neurospheres and brain organoids. Since ZIKV has been gradually established as a direct cause of central nervous system malformations, this study help to elucidate the etiological nature of the recently increasing number of microcephaly cases in Brazil.
    To read more, please click here.

     

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  • PELOBIOTECH: MEET US AT…

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    We are on the road again: We love to meet you personally at the Hausmesse with our partners in Mainz, April 14 at Foyer Forschungshaus Mainz, block #911. You can inform yourself about hot topics of cryopreservation, brandnew media tools and procedures of genetic analyzing, future developments of digital PCR systems and our entire Primary Cell Portfolio esp. on The New Generation of 3D models. Come and meet us there!

    Where to find us: download map

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  • Co-Culture of Aortic Endothelial & Smooth Muscle Cells

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    A novel role of endothelium in activation of latent pro-membrane type 1 MMP and pro-MMP-2 in rat aorta.

    Aims Aortic stiffness is an independent risk factor for progression of cardiovascular diseases. Degradation of elastic fibres in aorta due to angiotensin II (ANGII)-stimulated overactivation of latent membrane type 1 matrix metalloproteinase (MT1MMP) and matrix metalloproteinase-2 (MMP2) is regarded to represent an important cause of aortic stiffness. Therefore, clarification of the causal mechanisms triggering the overactivation of these MMPs is of utmost importance. This study addresses the endothelium as a novel key activator of latent pro-MT1MMP and pro-MMP2 in rat aorta.

    To read more, please click to our Partner’s CA Newsletter.

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  • Retinal Ganglion Cells Derived From Pluripotent Stem

    Stepwise differentiation through an enriched retinal progenitor intermediary facilitates the accomplishment of deriving retinal ganglion cells (RGCs) from human pluripotent stem cells (hPSCs), according to Research.  Sarah K. Ohlemacher, from Indiana University-Purdue University Indianapolis, and colleagues examined the process of differentiating hPSCs to a retinal lineage and attempted to derive RGCs from hPSCs.
    To read more please click here.

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  • Using Gene Editing to Delete HIV from Human T Cells

    In Allgemein on

    Researchers at Temple University used a CRISPR gene editing technique to remove HIV from the DNA of human cells grown in culture. Their study (“Elimination of HIV-1 Genomes from Human T-lymphoid Cells by CRISPR/Cas9 Gene Editing”) is published In Scientific Reports.

    According to senior investigator on the new study, Kamel Khalili, Ph.D., Laura H. Carnell Professor and Chair of the Department of Neuroscience, Director of the Center for Neurovirology, and Director of the Comprehensive NeuroAIDS Center at the Lewis Katz School of Medicine at Temple University (LKSOM), “Antiretroviral drugs are very good at controlling HIV infection. But patients on antiretroviral therapy who stop taking the drugs suffer a rapid rebound in HIV replication.” The presence of numerous copies of HIV weakens the immune system and eventually causes acquired immune deficiency syndrome, or AIDS.
    To read more, please click here.

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  • Removing Epigenetic Post-it Notes Returns Stem Cells to Unprimed State

    In Allgemein on

    A drug originally intended to treat leukemia has an unexpected power. It can reverse stem cell development, converting primed pluripotent stem cells to naïve pluripotent stem cells. The drug, called MM-401, effectively removes epigenetic markers from histones, depriving the cell’s DNA-reading machinery of indications of where to start reading. Stripped of its accumulated “Post-it notes,” the DNA instruction manual is like new. It lacks any indications that any sections should receive any special attention.

    To read more please click here.

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  • New Technique to Derive Naive Pluripotent Stem Cells from Human Embryos

    Researchers from the University of Cambridge have come up with a technique using which naive pluripotent stem cells from human embryos can be derived. These cells are having amazing feature that they can develop into all human tissue other than placenta.

    The promising technique could open new gateways for research into disorders like Down’s syndrome. The researchers are quite hopeful that the development could lead to advances in regenerative medicine.
    To read more, please click here.

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  • PELOBiotech: Welcome, Katja!

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    We are happy to announce that we enlarge our team and can serve you now even better.
    Katja Schulze joined our company in March and will be in charge of all customer questions in Germany and Switzerland. So go ahead and give her a call. 0049- 89- 517 286 59-0. She will be more than happy to be at your service.

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  • “Mini-Stomachs” That Produce Insulin When Transplanted

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    A team of researchers have succeeded in creating mini insulin-producing organs that can be implanted into a diabetic animal to maintain glucose levels, progress towards what they consider the future of regenerative medicine.

    The cells the researchers found are best at producing insulin when reprogrammed are pylotic cells — cells from the lower region of the stomach, called the “pylorus region.”

    They think that these cells work best because they are naturally very similar to the pancreatic beta cells that normally carry out this function. What they do better than other cells is respond to high glucose levels by producing insulin to normalize blood sugar levels.

    To read more, please click here.

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  • MEET US AT… IGLD 2016 in Hamburg

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    Feb. 25-26, 2016, Messehallen Hamburg: HAPPY BIRTHDAY IGLD

    Meet our CEO, Peter Frost, at the IGLD 2016.

    Listen to his lecture on “Magnetic Bioprinting in the field of Personalised Medicine”.

    And let us celebrate: Party till the morning and celebrate the 20th birthday of IGLD.

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