• Unlocking the Potential of SC in the Olfactory System

    As our understanding of stem cells has increased, the possibility of using stem cell therapies to treat disease is on the horizon. Barbara Murdoch, Ph.D., Assistant Professor at Eastern Connecticut State University, is studying #stem cells (#SC) found in the olfactory epithelium (#OE) with the aim of finding therapies for #neurodegeneration.

    The OE is one of the few tissues in the body which is known to regenerate neurons, preserving our sense of smell throughout our lives.

    “Have you ever had the experience where you smell something and the scent evokes a memory from years back in time?” asked Dr. Murdoch. “This is because not only can the stem cells in the OE divide and differentiate to replace the lost neurons, but they can also recreate the exact same connection in the brain as the neuron they are replacing.”

    See more here.

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  • Stanford: Protein primes Mouse SC to quickly Repair Injury

    Like drag car racers revving their engines at the starting line, #stem cells (SC) respond more quickly to injury when they’ve been previously primed with one dose of a single protein, according to a study from the #Stanford University School of Medicine.

    Mice given the priming protein recover muscle function more quickly after damage, their skin heals more rapidly and even the shaved area around the injury regrows hair more quickly, the study found. Harnessing the power of this protein may one day help people recover more quickly from surgery or restore youthful vigor to aging stem cells.
    Read more here.

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  • Artificial Thymus Fabricates Cancer Fighting T-Cells From Stem Cells

    In Allgemein, Stem Cell Culture, Stem Cells on

    A new strategy to produce human T cells has been developed by researchers at UCLA. T-cells are the white blood cells that fight against disease-causing intruders in the body.

    The system could be used to engineer T cells to search for and destroy cancer cells. It could be a valuable step toward manufacturing a readily available supply of T cells for treating many different types of cancer.

    The thymus, located in the front of the heart, plays an important role in the immune system. It uses blood stem cells to make T cells, which help the body fight infections and have the ability to eliminate cancer cells. But as people grow older or become ill, the thymus isn’t as efficient at making T cells.

    To read more, please click here

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  • Waiting to Reprogram Your Cells? Don’t Hold Your Breath

    This is the stuff from which the cartilage was grown: induced pluripotent stem cells, often called #iPS cells. Guiding a recent tour of a Kyoto University lab, a staff member holds up a transparent container. Inside are tiny pale spheres, no bigger than peas, floating in a clear liquid. “This is cartilage,” explains the guide, Hiroyuki Wadahama. “It was made here from human iPS cells.”

    A monitor attached to a nearby microscope shows a mass of pink and purple dots. This is the stuff from which the cartilage was grown: induced pluripotent stem cells, often called iPS cells. Scientists can create these seemingly magical cells from any cell in the body by introducing four genes, in essence turning back the cellular clock to an immature, nonspecialized state. The term “pluripotent” refers to the fact iPS cells can be “reprogrammed” to become any type of cell, from skin to liver to nerve cells. In this way they act like embryonic stem cells (#SC) and share their revolutionary therapeutic potential—and as such, they could eliminate the need for using and then destroying human embryos. Also, iPS cells can proliferate infinitely.
    Read more here.

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  • Vision Saved by first iPS Cell Treatment

    In Allgemein, Stem Cell Culture, Stem Cells on

    A woman in her 80s has become the first person to be successfully treated with induced pluripotent stem (#iPS) cells. A slither of laboratory-made retinal cells has protected her eyesight, fighting her age-related macular degeneration – a common form of progressive blindness.

    Such stem cells can be coaxed to form many other types of cell. Unlike other types of stem cell, such as those found in an embryo, induced pluripotent ones can be made from adult non-stem cells – a discovery that earned a Nobel prize in 2012.

    Now, more than a decade after they were created, these stem cells have helped someone. Masayo Takahashi at the RIKEN Laboratory for Retinal Regeneration in Kobe, Japan, and her team took# skin cells from the woman and turned them into iPS cells. They then encouraged these to form retinal pigment epithelial cells, which are important for supporting and nourishing the retina cells that capture light for vision.

    Read more here.

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  • How the Body Controls Stem Cells

    #Stem cells are unspecialized cells that can develop into any type of cell in the human body. So far, however, scientists only partially understand how the body controls the fate of these all-rounders, and what factors decide whether a stem cell will differentiate, for example, into a blood, liver or nerve cell. Researchers have now identified an ingenious mechanism by which the body orchestrates the regeneration of red and white blood cells from #progenitor cells.
    Read more here.

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  • ReSyn Biosciences participating as Industrial Partner in Horizon 2020 BioCapture Project

    In Allgemein on

    We congratuate our partner ReSyn to be part of a Horizon 2020 project. BioCapture is a European Training Network (ETN) funded by the European Commission under the #Horizon 2020 Marie Skłodowska-Curie Action. The network consists of 15 research groups, spread across 11 universities and institutes and 4 industrial partners in 6 different countries that have come together to train a new generation of chemists/physicists/biologists through an EU-wide PhD training network. The main aim of this interdisciplinary project is to discover new and improved ways to diagnose and treat cancer.

    BioCapture offers an opportunity for 11 early stage researchers (ESR’s) to develop molecularly imprinted polymers (MIP’s), also referred to as “plastic antibodies”, for specific application to the discovery and detection of cancer #biomarkers.
    Read more here or at Linked-In.

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  • 3D Tissue Culture Model Mimics Gut Infections

    In Allgemein on

    With threats like zika, ebola, #SARS and tuberculosis increasing, researchers are using predictive tissue culture models to more accurately reflect how humans respond to pathogens.

    The lack of sophisticated models has greatly slowed the ability to understand infectious disease from both the host and the pathogen perspective.

    One approach to address this problem is the use of predictive tissue culture models. To develop these models, an understanding of how cells and tissues in our bodies function in a #3D context is required.

    A research team from the Arizona State University Biodesign Institute team and NASA’s Johnson Space Center, have developed a realistic 3D co-culture model, which incorporates an important immune defense cell type found in the intestine, macrophages, key cells targeted by salmonella, a leading cause of food poisoning and systemic disease worldwide.

    Read more here.

     

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  • NEWS: Meet us at…

    In 3D Cell Culture, Allgemein on

    ELRIG Forum 2017 in Darmstadt, Germany.
    This interesting meeting in the Wissenschafts- und Kongresszentrum “darmstadtium” starts today, March 9, 2017 any minute.

    Topic: Phenotypic Screening und #3D Cellular Screening Models
    So come along and meet PELOBIOTECH at #Elrig Forum, Booth 28, and discuss with Dr. Peter Frost, CEO, and other scientists the latest approaches of academic and industrial research.

    More information here.

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  • SC treatment may Restore Vision

    In Allgemein, Stem Cell Culture on

    Researchers working as part of the University of Georgia’s Regenerative Bioscience Center have developed a new way to identify and sort #stem cells that may one day allow clinicians to restore vision to people with damaged corneas using the patient’s own eye tissue. They published their findings in Biophysical Journal.

    The #cornea is a transparent layer of tissue covering the front of the eye, and its health is maintained by a group of cells called limbal stem cells. But when these cells are damaged by trauma or disease, the cornea loses its ability to self-repair.

    Raed more here.

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  • Quit smoking? Cigarette smoke blocks self-healing processes

    In Allgemein on

    Smoke from cigarettes blocks self-healing processes in the lungs and consequently can lead to chronic obstructive #pulmonary disease (COPD), says a new study. Researchers at the #Helmholtz Zentrum München, partner in the German Centre for Lung Research (DZL), and their international colleagues have reported this finding in the American Journal of Respiratory and Critical Care Medicine.

    Cough, bronchitis and breathing difficulties are the typical manifestations of COPD. Exact figures are not available, but estimates assume that 10 to 12% of adults over 40 years of age in Germany suffer from the disease. Experts estimate the national economic costs of the disease at almost six billion euros annually. Scientists around the world are attempting to discover how the disease develops and what biological adjustments can be made to stop it.

    To read more click here please.

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  • Scientists rejuvenate Blood by Cell Reprogramming

    In Allgemein on

    When we are young, our blood #stem cells produce an even and well-balanced number of red and white blood cells according to need. As we age, however, the capacity of the blood stem cells to produce the number of blood cells we need declines. Like it or not, your body gradually loses its capacity for producing blood as you age — that’s why immune deficiencies, leukemia and other blood conditions become more likely with time. Scientists may have found a way to turn back the clock, though. They’ve found a way to rejuvenate blood by reprogramming the stem cells that create it. The team effectively “resets” the stem cells by turning them into #iPS cells, which can generate any kind of cell. When they once again form blood stem cells, it’s as if they were brand new.

    “This type of age-related change can have major consequences as it can lead to an imbalance in stem cell production. For example, a reduced production of immune cells or excessive production of other types of cells can be a precursor to leukaemia”, explains David Bryder, who headed the study at Lund University.

    Read more here and here.

     

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  • How Cerebral Malaria Attacks the Brain

    In Allgemein on

    Most clinicians know that cerebral #malaria, a complication associated with the all-too-common mosquito-borne virus that affects much of the developing world, can be deadly; however, relatively little is known about exactly how the disease attacks the human #brain.

    That may be changing. Using mouse models the authors of a study demonstrated that cytotoxic #T-cells attack cerebral blood vessels leading to swelling in the brain. They believe that their findings mirror how cerebral malaria affects the human brain. The complication is associated with Plasmodium falciparum malaria, the most dangerous form of the virus. Exact figures on its incidence are not available; however, it is believed that more than 500,000 children develop cerebral malaria annually in Africa alone, and that it causes as many as 1 million deaths worldwide each year. It is fatal in as many as 30% of the people it afflicts. Sufferers typically experience seizures and may lapse into a coma.

    See more here.

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  • Mitomycin C-treated iPS cells as a Safe Delivery System

    In Allgemein, iPS media, Stem Cell Culture on

    Human-induced pluripotent stem cells (iPS) possess an intrinsic tumor tropism ability. However, #iPS cells are impeded in clinical applications of tumor therapy due to the formation of teratomas and their survival in normal organs such as the liver, lungs, spleen and kidneys. #Mitomycin C (MMC) can overcome this limitation by suppressing iPS proliferation. Herein, we fabricated a safe delivery system of iPS cells treated with MMC loading with gold nanorods (AuNRs) for the targeted photothermal treatment of gastric cancer. Our results showed that the tumor cells were efficiently killed by the heat generated from the gold nanorods, and the iPS cells ultimately died due to the action of #MMC seven days after the photothermal treatment. This suggested that pre-treated iPS cells with MMC can be used as a novel and safe approach for targeted tumor therapy. This paves the road for clinical translation in the future.

    To read more please click here

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  • FREE Webinar: MSCs and the challenges of Xeno-free Media

    In Allgemein on

    Sign up now!
    Tue, Feb 21, 2017 10:00 AM – 11:00 PM CET

    presented by Peter Frost, PhD, CEO, PELOBIOTECH

    How the right media effects your MSC culture

    We will focus in this webinar on the

    – easy culture of MSC from different tissues
    -Xeno-free culture systems
    – best Cells, Media and Reagents for MSCs
    – Overview, what works best and what challenges do we face now and in the future
    – why it is so important to find and define the right conditions.

    Please share this information with your co-workers and friends. Thank you.

    Your PELOBiotech-Team

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  • #Regenerative Medicine Has a Bright Future

    In Allgemein, regenerative medicine on

    The Army is already using regenerative medicine to help wounded soldiers while #Duke University is researching it to help repair spinal cord injuries.

    U.S. Army scientists, working with medical technology companies, have successfully tested and used products and techniques that have enabled Army surgeons to replace the severely burned skin of soldiers as well as transplant new hands and even faces.

    At Duke University, researchers are studying zebra fish to learn how science and medicine might someday be able to regenerate severed human spinal cords.

    These examples — one already in practice and the other in the early research stages — illustrate the potential that regenerative medicine offers for the future of medical care.

    This research aims to go beyond easing the pain of life-threatening illnesses by changing the way diseases affect the body and then eradicating them.
    To read full article, click here.

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  • Cold Chain Logistics: Innovation in Biopreservation of Cell Therapies and Tissues

    In Allgemein on

    Cold chain logistics can determine success or failure for any biotech company shipping time and/or temperature-sensitive products, many of which have the potential to save lives. These include traditional solid #organs intended for transplantation into a recipient, and also a new and growing class of novel cellular therapies and engineered tissue products.

    In the high-profile and promising personalized medicine arena, a circular process is used with cold chain logistics playing a critical part in two steps. For autologous cell therapies using chimeric antigen receptor and other types of #T cells targeting various cancers, the process involves removing source material such as bone marrow, peripheral blood, or adipose tissue from a patient, shipping these to a processing and manufacturing facility, manufacturing a dose of therapeutic cells, and then shipping the cells back to the original clinical site for reinfusion into the same patient. Due to their fragile nature and limited shelf life outside the body, cold chain technologies are used to maintain a reduced temperature of these biologic materials, to slow or stop metabolic activity during transport.

    To read more, please click here

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  • NEW PELOBiotech News 02/17

    In Allgemein on

    PELONEWS 02/2017
    Dear scientist and colleague,

    we have our new Productlist for #Human Primary Cells, #SC and Media available. Just pick your favorite.
    Also there are more and more projects going on regarding MSCs. That´s why we get up close in our next FREE webinar mid Feburary. Just sign up and we send the record to you afterwards – even if you have no time on Tuesdays.

    To get more, plcase click here

    weiter Lesen
  • Shape of Tumor may affect whether Cells can Metastasize

    In Allgemein, Stem Cells on

    Only a few cells in a cancerous tumor are able to break away and spread to other parts of the body, but the curve along the edge of the tumor may play a large role in activating these tumor-seeding cells, according to a new University of Illinois study.

    Using engineered tissue environments in various shapes and patterns, the study of skin cancer found that the more curved the cell cultures were, the more cancer cells at the edges displayed markers o f#stem cell characteristics – the key to spreading to other tissues.

    This has potential for furthering our understanding of cancer as well as developing personalized treatment plans.

    Led by Kristopher Kilian, a professor of materials science and engineering, and Timothy Fan, a professor of veterinary medicine, the researchers published their findings in the journal Nature Materials.

    “The most dangerous part of cancer is metastasis,” Kilian said. “Some cells that we call #cancer stem cells adopt deadly characteristics where they can travel through the bloodstream to other tissue and form new tumors.”

    To read more, please click here

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  • ‘Totipotent’ SC capable of forming Viable Embryo

    In Allgemein, Cell Culture, Stem Cell Culture on

    #Stem cells with characteristics of totipotency — capable of creating all the tissue types needed to build and sustain an embryo — have been created in mice by a California-led research team.

    Researchers found that a #microRNA called miR-34a prevents totipotency. Pluripotent mouse cells deficient in that microRNA acquired signs of totipotency.

    The feat makes it feasible to explore the molecular basis of totipotency, said the researchers in a study, that was led by Yong Jin Choi and Chao-Po Lin of UC Berkeley. Lin He, also of UC Berkeley, was the senior author. It can be found at j.mp/totipot.

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