Conversion of adult #, endothelium to immunocompetent #hematopoietic stem cells

Conversion of adult #, endothelium to immunocompetent #hematopoietic stem cells

This paper is great promise:
Developmental pathways that orchestrate the fleeting transition of endothelial cells into haematopoietic stem cells remain undefined. Here we demonstrate a tractable approach for fully reprogramming adult mouse endothelial cells to haematopoietic stem cells (rEC-HSCs) through transient expression of the transcription-factor-encoding genes Fosb, Gfi1, Runx1, and Spi1 (collectively denoted hereafter as FGRS) and vascular-niche-derived angiocrine factors.

Read more here.
@WeillCornell @Nature

https://twitter.com/endothelialnews