ES/iPS: Epigenetic program leading to Vessel Differentiation

ES/iPS: Epigenetic program leading to Vessel Differentiation

Clarification of how human blood vessels are constructed is desperately needed to advance regenerative medicine. Researchers investigated the changes in gene functions that occur when stem cells become vascular cells. They found that the histone code, which alters the transcriptional state of the gene, changes over time as #stem cells differentiate into blood vessels in response to a stimulus.

#Regenerative medicine has made remarkable progress due to research with embryonic stem (#ES) cells and induced pluripotent stem (#iPS) cells. However, the mechanism of how blood vessels are constructed from these undifferentiated cells has not yet been clarified. During the creation of new blood vessels, the vascular endothelial growth factor (#VEGF) protein differentiates stem cells into vascular endothelial cells and stimulates them to create new blood vessels. Researchers at Kumamoto University added VEGF to undifferentiated ES cells and tracked the behavior of the entire genome and epigenome changes over time in vitro.

Read more here.