• JOIN Free Webinar: Flat biology is out

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    Gain Fresh Insights on your Drug Candidates on 3D in vitro systems
    Date: Tue, July 11, 2017
    Time: 4 PM (CEST)
    presented by Angel Garcia Martin, CEO, StemTek Therapeutics

    Cancer is the number one cause of death in the developed world, expected to increase in the next decades. For advanced cancer, survival rates have remained steady for the last 30 years. Only about 10% of the compounds progress successfully through clinical development. Many drugs fail during clinical trials, especially during phase III, which is the most expensive phase of clinical development,….

    To read more, please click here

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  • Stem Cells: The Future of Medicine

    In Allgemein, Stem Cell Culture on

    All across the world, scientists have begun clinical trials to try and do just that, by making use of the incredible power and versatility of #stem , which are special cells that can make endless copies of themselves and transform into every other type of cell.

    While human embryos contain #, which help them to develop, the use of those cells has been controversial. The scientists are using induced pluripotent stem cells instead, which are other cells that have been reprogrammed to behave like stem cells.

    “There are still significant challenges that we need to overcome, but in the long run we might even be able to create organs from stem cells taken from patients. That would enable rejection-free transplants,” said Professor Janet Rossant, a pioneer in the field.

    In Canada, Prof Rossant chaired the working group of the Canadian Institutes of Health Research on Stem Cell Research, establishing guidelines for the field. These guidelines helped to keep the field alive in Canada, and were influential well beyond the country’s borders.

    In 2006, Japanese researchers succeeded in taking from adult mice and reprogramming them to behave like embryonic stem cells. These revolutionary, induced pluripotent stem (IPS) cells allowed scientists to sidestep the ongoing controversy.

    Read more here.

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  • Can sugar-coated nanomaterial get bones to grow?

    In Allgemein, regenerative medicine on

    Orthopedic spine surgeons don’t have a definitive way to promote bone growth, but a new bioactive nanomaterial, powered by sugar, shows promise at stimulating #regeneration.

    While the new method has only been studied in an animal model of spinal fusion, researchers say it could readily translate to humans.
    Read more here.

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  • Hidden Immune Cells play Key Role

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    Northwestern Medicine scientists have discovered that a subset of immune cells called nonclassical monocytes (#NCMs), previously unknown to reside in the lungs, play a key role in driving , primary graft dysfunction (PGD), the leading cause of death after lung #transplantation.

    The study, published in Science Translational Medicine, also demonstrates targeting these cells could lead to novel treatments for PGD, a complication that currently impacts more than half of transplant patients.
    Read more here.

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  • FREE Webinar: Join us now… EASY – New Ways for Endothelial Cell Culture

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    EASY – New Ways for Endothelial Cell Culture
    Neue Medien und Optimierung für Endothelzellen

    Date:  Tue, June 20, 2017, 10 AM

    presented by Lothar Steeb, PhD, CSO, PELOBIOTECH

    Endothelzellkultivierung ist seit Jahrzehnten verbreitet und wird immer noch wichtiger. Parallel dazu ist das Angebot an Endothelzellen von ehemals #HUVEC aus der Nabelschnurvene und mikrovaskulären Endothelzellen aus der Haut extrem angewachsen. Wir können heute mehr als 30 verschiedene…
    More here

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  • Why the Heart does not Repair itself?

    In Allgemein, regenerative medicine on

    New Study: Heart muscle is one of the least renewable tissues in the body.
    According to a new study, a group of researchers has fund that #heart muscle is one of the least renewable tissues in the body, which is one of the reasons that heart disease is the leading cause of death for both men and women. The team has studied pathways known to be involved in heart cell functions and discovered a previously unknown connection between processes that keep the heart from repairing itself. The study was published in the journal @Nature. “We are investigating the question of why the heart muscle doesn’t renew. n this study, we focused on two pathways of cardiomyocytes or heart cells; the Hippo pathway, which is involved in stopping renewal of adult cardiomyocytes, and the dystrophin glycoprotein complex (DGC) pathway, essential for #cardiomyocyte normal functions,” shared senior author Dr. James Martin, professor and Vivian L. Smith Chair in #Regenerative Medicine at Baylor College of Medicine.

    Read more here.

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  • NEW: Multi-mode HILIC Microparticles for pre-Mass Spectrometry Sample Cleanup

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    Resyn Biotech  launches a new product at ASMS 2017: MagReSyn® HILIC MagReSyn® HILIC provides a highly reproducible, unbiased and fully automatable solution for parallel protein sample clean-up prior to MS analysis. Please visit our partner at Booth 408 at the 65th ASMS Conference on Mass Spectrometry and Allied Topics (ASMS) 2017 in Indianapolis, USA, June 4-8, 2017.

    The range of possible sample contaminants, variability in starting material, & range of possible reagents for sample preparation has resulted in variability in data generated from #mass spectrometry (MS). Current methodologies and tools for sample clean-up prior to digestion and MS analysis require the use of in-line column chromatography, desalting columns/membranes, and or packed tips for partitioning. Although some of these techniques are broadly applicable, they are not routinely automatable, or don’t provide the option for parallel processing for high-throughput. In order to fully automate clean-up we have developed a versatile magnetic mixed-mode #HILIC with broad applicability for the removal of common contaminants required in the solubilization and denaturation of proteins. The use of magnetic beads are gaining in popularity due to the ability to automate clean-up procedures, reducing sample handling, and providing massively parallel sample processing.

    For more information see here.

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  • Conversion of adult #, endothelium to immunocompetent #hematopoietic stem cells

    This paper is great promise:
    Developmental pathways that orchestrate the fleeting transition of endothelial cells into haematopoietic stem cells remain undefined. Here we demonstrate a tractable approach for fully reprogramming adult mouse endothelial cells to haematopoietic stem cells (rEC-HSCs) through transient expression of the transcription-factor-encoding genes Fosb, Gfi1, Runx1, and Spi1 (collectively denoted hereafter as FGRS) and vascular-niche-derived angiocrine factors.

    Read more here.
    @WeillCornell @Nature

    https://twitter.com/endothelialnews

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  • ReSyn Biosciences is a Consortium Member of the BioCapture Network

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    Our Partner #ReSyn Biosciences became a member of the BioCapture network. This is a European Training Network (ETN) funded by the European Commission under the #Horizon 2020 Marie Skłodowska-Curie Action. The network consists of 15 research groups, spread across 11 universities and institutes and 4 industrial partners in 6 different countries that have come together to train a new generation of chemists/phycisists/biologists through an EU-wide #PhD training network. The main aim of this interdisciplinary project is to discover new and improved ways to diagnose and treat cancer.
    Read more here.

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  • ES/iPS: Epigenetic program leading to Vessel Differentiation

    Clarification of how human blood vessels are constructed is desperately needed to advance regenerative medicine. Researchers investigated the changes in gene functions that occur when stem cells become vascular cells. They found that the histone code, which alters the transcriptional state of the gene, changes over time as #stem cells differentiate into blood vessels in response to a stimulus.

    #Regenerative medicine has made remarkable progress due to research with embryonic stem (#ES) cells and induced pluripotent stem (#iPS) cells. However, the mechanism of how blood vessels are constructed from these undifferentiated cells has not yet been clarified. During the creation of new blood vessels, the vascular endothelial growth factor (#VEGF) protein differentiates stem cells into vascular endothelial cells and stimulates them to create new blood vessels. Researchers at Kumamoto University added VEGF to undifferentiated ES cells and tracked the behavior of the entire genome and epigenome changes over time in vitro.

    Read more here.

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  • How to Sequence DNA in Space

    In Allgemein, Cell Culture on

    “You’re tending to the cells—you have to change the media [in the #cell culture], you have to resupply them with nutrients”, says Kate Rubins, the first person to carry out an experiment in microgravity.

    The International Space Station is one big research laboratory. Its earliest research objectives, back in 2000, were pretty straightforward: keep humans alive. Since then, the number of experiments conducted aboard the station has ballooned, and astronauts and cosmonauts spend their days studying how terrestrial science and technology works in microgravity. Over the years, the station’s residents have grown zucchini, beheaded flatworms, maneuvered humanoid robots, tended to mouse embryos, watched the muscles of zebrafish atrophy, and drawn their own blood, using their own bodies as test subjects. Scrolling through NASA’s full list of experiments, one gets the sense that almost any experiment that can be done in a lab on Earth can be replicated in one floating 200 miles above.
    Learn more here.

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  • Meet us today at …

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    Kompetenznetzwerk für #Stammzellforschung NRW/ #StemCell Meeting NRW 2017
    Date: May 16-17 , 2017 in Münster with our partner REPROCELL at booth #16

    Join this important 9th meeting SC meeting. It takes place from 16 – 17 May 2017 at the Halle Münsterland convention center in Münster, Germany.

    Funding from the Ministry of Innovation, Science and Research of the state of North Rhine-Westphalia (NRW) has made it possible to run this event for the ninth time in succession with consistently high-caliber speakers. The network’s program committee has identified the most important current issues in stem cell research and has invited internationally leading experts to take part.

    The program covers a broad range of stem cell research issues. Here too, you will find information on our world-class speakers who include Alexander Meissner (Cambridge/Berlin), Juan Carlos Izpisua Belmonte (La Jolla), Robert Weinberg (Cambridge), Michele De Luca (Modena) and many others. Hans Clevers (Utrecht) will hold the keynote speech.
    More details: http://www.kongress.stammzellen.nrw.de/

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  • Join FREE Webinar on… NOW: Cell Sourcing – Do you get the cells you really need?

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    How to put an end to cancer metastatis
    presented by Peter Frost, PhD, CEO, PELOBIOTECH
    To register for free just click here
    Upcoming 30 min. May 18 2017
    10 AM (CEST))
    English
    TODAY: Cell Sourcing – Do you get the cells you really need? 
    presented by Peter Frost, PhD, CEO, PELOBIOTECH

     

    30 min. May 16 2017
    10 AM (CEST))
    English

    To register for free just click here

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  • Intracellular Uptake of Macromolecules by Brain Lymphatic Endothelial Cells

    The lymphatic system controls fluid homeostasis and the clearance of macromolecules from interstitial compartments. In mammals brain lymphatics were only recently discovered, with significant implications for physiology and disease. We examined #zebrafish for the presence of brain lymphatics and found loosely connected endothelial cells with lymphatic molecular signature covering parts of the brain without forming endothelial tubular structures.

    These brain lymphatic #endothelial cells (#BLECs) derive from venous endothelium, are distinct from macrophages, and are sensitive to loss of Vegfc. BLECs endocytose macromolecules in a selective manner, which can be blocked by injection of mannose receptor ligands. This first report on brain lymphatic endothelial cells in a vertebrate embryo identifies cells with unique features, including the uptake of macromolecules at a single cell level. Future studies will address whether this represents an uptake mechanism that is conserved in mammals and how these cells affect functions of the embryonic and adult brain.

    To read more, click here.

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  • Reprogramming Adult Cells in vivo to Treat Parkinson’s

    In Allgemein, iPS media on

    Reprogramming of #iPSCs has given rise to the emergence of #reprogramming approaches that target other types of cells including those of meso-, endo- and ectodermal origin — for example, the generation of functional neurons from fibroblasts which has been reported in a number of recent studies. These are, potentially, therapeutically powerful strategies to target severe and elusive diseases.

    One such disease is #Parkinson’s, a disorder of the nervous system affected by the death of neurons and impaired dopamine signaling. Work from the Karolinska Institutet with collaborators at Stanford University, the University of Vienna and Malaga University described, for the first time, a new approach to treating Parkinson’s which merges cell therapy alongside genetic reprogramming of cells for enhanced therapeutic targeting.
    To read more, please click here.

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  • Unlocking the Potential of SC in the Olfactory System

    As our understanding of stem cells has increased, the possibility of using stem cell therapies to treat disease is on the horizon. Barbara Murdoch, Ph.D., Assistant Professor at Eastern Connecticut State University, is studying #stem cells (#SC) found in the olfactory epithelium (#OE) with the aim of finding therapies for #neurodegeneration.

    The OE is one of the few tissues in the body which is known to regenerate neurons, preserving our sense of smell throughout our lives.

    “Have you ever had the experience where you smell something and the scent evokes a memory from years back in time?” asked Dr. Murdoch. “This is because not only can the stem cells in the OE divide and differentiate to replace the lost neurons, but they can also recreate the exact same connection in the brain as the neuron they are replacing.”

    See more here.

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  • Stanford: Protein primes Mouse SC to quickly Repair Injury

    Like drag car racers revving their engines at the starting line, #stem cells (SC) respond more quickly to injury when they’ve been previously primed with one dose of a single protein, according to a study from the #Stanford University School of Medicine.

    Mice given the priming protein recover muscle function more quickly after damage, their skin heals more rapidly and even the shaved area around the injury regrows hair more quickly, the study found. Harnessing the power of this protein may one day help people recover more quickly from surgery or restore youthful vigor to aging stem cells.
    Read more here.

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  • Artificial Thymus Fabricates Cancer Fighting T-Cells From Stem Cells

    In Allgemein, Stem Cell Culture, Stem Cells on

    A new strategy to produce human T cells has been developed by researchers at UCLA. T-cells are the white blood cells that fight against disease-causing intruders in the body.

    The system could be used to engineer T cells to search for and destroy cancer cells. It could be a valuable step toward manufacturing a readily available supply of T cells for treating many different types of cancer.

    The thymus, located in the front of the heart, plays an important role in the immune system. It uses blood stem cells to make T cells, which help the body fight infections and have the ability to eliminate cancer cells. But as people grow older or become ill, the thymus isn’t as efficient at making T cells.

    To read more, please click here

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  • Waiting to Reprogram Your Cells? Don’t Hold Your Breath

    This is the stuff from which the cartilage was grown: induced pluripotent stem cells, often called #iPS cells. Guiding a recent tour of a Kyoto University lab, a staff member holds up a transparent container. Inside are tiny pale spheres, no bigger than peas, floating in a clear liquid. “This is cartilage,” explains the guide, Hiroyuki Wadahama. “It was made here from human iPS cells.”

    A monitor attached to a nearby microscope shows a mass of pink and purple dots. This is the stuff from which the cartilage was grown: induced pluripotent stem cells, often called iPS cells. Scientists can create these seemingly magical cells from any cell in the body by introducing four genes, in essence turning back the cellular clock to an immature, nonspecialized state. The term “pluripotent” refers to the fact iPS cells can be “reprogrammed” to become any type of cell, from skin to liver to nerve cells. In this way they act like embryonic stem cells (#SC) and share their revolutionary therapeutic potential—and as such, they could eliminate the need for using and then destroying human embryos. Also, iPS cells can proliferate infinitely.
    Read more here.

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